Role of early continuous venovenous hemodiafiltration in septic shock and multiorgan failure

Continuous venovenous hemodiafiltration for renal failure and sepsis.

Liver perfusion in sepsis, septic shock, and multiorgan failure.

Sepsis causes significant alterations in the hepatic macro- and microcirculation. Diverging views exist on global hepatic blood flow during experimental sepsis because of the large variety in animal and sepsis models. Fluid-resuscitated clinical sepsis is characterized by ongoing liver ischemia due to a defective oxygen extraction despite enhanced perfusion. The effects of vasoactive agents on ...

Pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration.

The objective of this study was to analyze the pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration. Six patients received 15 mg of isepamicin per kg of body weight. The mean isepamicin concentration peak in serum was 62.88 +/- 18.20 mg/liter 0.5 h after the infusion. The elimination half-life was 7. 91 +/- 0.83 h. The mean total body clearance was 1.75 +/- 0.28 liters/...

Carbamazepine Intoxication Unresponsive to Continuous Venovenous Hemodiafiltration

s: Carbamazepine (CBZ) intoxication can be associated with severe toxicity. Highly protein-bounded, CBZ is not removed efficiently through conventional hemodialysis. we observed that serum CBZ level was decreased minimally by albumin-enhanced CVVHDF with low dialysate flow. Therefore, albumin-enhanced CVVHDF with high dialysate flow should be considered in severe CBZ intoxication, if hemoperfus...

Continuous venovenous hemodiafiltration increased survival more than did continuous hemofiltration in acute renal failure.

M e t h o d s Design: Randomized controlled trial. Allocation: Concealed.* Blinding: Unblinded.* Follow-up period: 90 days. Setting: Intensive care units (ICUs) in Geneva, Switzerland. Patients: 206 patients (mean age 63 y, 61% men) with acute renal failure (urine output < 200 mL/12 h despite treatment or blood urea nitrogen > 30 mmol/L with urine output < 1500 mL/12 h). Exclusion criteria were...